not do, call the toll-free
number listed at the end of these instructions.
If you have any questions about your dose or your treatment
with GENOTROPIN, call your healthcare provider.

GENOTROPIN PEN 12 is a device used to mix and inject doses of GENOTROPIN Lyophilized Powder
(somatropin [rDNA origin] for injection). Use this device only for administration of GENOTROPIN.


What You Will Need

GENOTROPIN PEN 12
13.8 mg two-chamber cartridge of GENOTROPIN
Alcohol swab
29-gauge, 30-gauge, or 31-gauge Becton Dickinson pen needle
Proper disposal container for used needles

Components of the GENOTROPIN PEN 12




Before You Begin
To help prevent infection, always wash your hands with soap and water before
preparing or using the GENOTROPIN PEN 12.


1.
Attach the Needle

Remove the front cap from the
GENOTROPIN PEN 12.
Unscrew the metal front part and detach it
from the plastic body of the pen.
Remove the paper covering from the back of a
new needle.
Screw the needle onto the metal front part by
gently turning it clockwise (to the right).
2


2. Insert the Two-Chamber Cartridge of
GENOTROPIN
Use only the 13.8 mg cartridge.
Wipe the metal/rubber tip of the cartridge with
an alcohol swab.
Insert the cartridge into the metal front part of
the pen, with the metal/rubber tip towards the
needle end. Push the cartridge firmly into
place.


3. Prepare the Body of the Pen
Press the red release button to release the
black/white injection knob.
Turn the black/white injection knob
counterclockwise (to the left) as far as it will
go.
Check that the plunger rod is not visible
through the window at the top of the plastic
body of the pen. Do NOT proceed if the
plunger rod is visible, as the medication will
not be properly mixed. Instead, press the red
release button again to draw back the plunger
rod. After the rod is no longer visible through
the window, proceed to the next step.


4. Screw the GENOTROPIN PEN 12 Together
Hold the metal front part upright.
While holding upright, gently screw the metal
front part and the plastic body back together.
This mixes the diluent in the rear chamber of
the cartridge with the growth hormone powder
in the front chamber.
Gently tip the assembled GENOTROPIN PEN
12 from side to side to help dissolve the
powder completely. DO NOT SHAKE as that
might inactivate the growth hormone.


5. Examine Solution and Release Trapped Air
Look through the cartridge windows in the
metal front part of the pen and make sure the
drug solution is clear. If you see particles or if
the solution is discolored, DO NOT INJECT
IT. Instead, call the toll-free number listed at
the end of these instructions.
Remove the outer needle cap and save it for
later.
Remove and discard the inner needle cap. Be
careful not to touch the exposed needle.
Remove any trapped air from the solution as
follows:
a) Turn the black/white injection knob
3
clockwise (to the right) one click.
This will line up the white mark on
the injection knob and the black mark
on the body of the pen.
b) Hold the GENOTROPIN PEN 12
upright and gently tap the metal front
part with your finger to move any air
bubbles to the top.
c) Push the black/white injection knob
all the way in. You will see a drop of
liquid appear at the needle point. Any
trapped air has now been released.
d) If no liquid squirts out, press the red
release button and turn the
black/white injection knob clockwise
(to the right) until it clicks once.
Repeat steps b) and c).
If desired, attach the reusable needle guard
over the needlepush until it snaps in place.
Again, be careful not to touch the exposed
needle. To avoid an accidental needle stick,
grip the sides of the needle guard; never push
on the end.


6. Dial Your Prescribed Dose
Press the red release button to reset the device.
The black/white injection knob will pop out
and the dose display window will read 0.0.
With the dose display activated, turn the
black/white injection knob clockwise (to the
right) until your prescribed dose is displayed.

If you go too far, just turn the knob back the
other way until the correct dose is displayed.

NOTE: If you turn the black/white injection
knob backwards beyond zero after a cartridge
has been inserted, the pen display will show (-
-). Just turn the injection knob forward
(clockwise) until numbers reappear on the
dose display.

The GENOTROPIN PEN 12 contains a
battery for the dose display. To save the
batterys energy, the dose display is activated
for two minutes and then automatically
disappears. Although the display is no longer
visible, the dose remains available for
delivery.
NOTE: Each click of the black/white
injection knob equals a two-tenth-of-a
milligram dose (or 0.2 mg). One clickor 0.2
mgis the minimum possible dose per
injection; 20 clicksor 4.0 mgis the
maximum possible dose per injection. If you
accidentally dial more than the maximum 4.0
mg dose, some liquid may emerge from the
tip. This is normal and will not affect your
injectionsimply dial back to the correct
4
dose.


7. Inject your GENOTROPIN
Select and prepare an appropriate injection
site, as directed by your healthcare provider.
Pinch a fold of skin at the injection site firmly,
and push the GENOTROPIN PEN 12 into the
skinfold at a 90° angle. Push the pen down as
far as possible.
Push the black/white injection knob until it
clicks. Wait at least 5 seconds and then
withdraw the GENOTROPIN PEN 12.


8. Discard the Needle and Store the
GENOTROPIN PEN 12
Remove and store the needle guard, if you
used one.
Carefully replace the outer protective cap on
the needle, as instructed by your healthcare
provider.
Unscrew the needle and discard it in a proper
disposal container. NEVER REUSE A
NEEDLE.
Replace the front cap, then put the
GENOTROPIN PEN 12 back in its protective
case. Store it in the refrigerator at 2
° to 8°C
(36
° to 46°F) until your next injection.


Your Next Injection
If you already have a drug cartridge in your GENOTROPIN PEN 12, prepare the pen and administer your
dose as follows:
Remove the front cap of the GENOTROPIN PEN 12.
Remove the paper covering from the back of a new needle.
Screw the needle onto the metal front part of the pen by turning it clockwise (to the right).
Remove the outer and inner needle caps.
Follow the instructions above, starting with step 6.

To Replace the Cartridge
Press the red release button to reset the GENOTROPIN PEN 12.
Turn the black/white injection knob counterclockwise (to the left) as far as it will go.
Unscrew the metal front part and remove the empty cartridge.
Discard the empty cartridge as instructed by your healthcare provider.
To insert a new cartridge and prepare the GENOTROPIN PEN 12 for use, follow the instructions
above.

Storage
Between uses, store your GENOTROPIN PEN 12 in the refrigerator
at 2
° to 8°C (36° to 46°F)
in its
protective case. Always remove the needle before storing. Do not freeze. Protect from light. Discard the
cartridge in your GENOTROPIN PEN 12 within 28 days after reconstitution (mixing of the growth
hormone powder with the diluent) even if the cartridge is not empty.

5
When traveling, keep your GENOTROPIN PEN 12 in its protective case and carry it in an insulated bag to
protect it from heat or freezing. Put it back in the refrigerator as soon as possible.

Caring For Your GENOTROPIN PEN 12
No special maintenance is required. To clean the GENOTROPIN PEN 12, wipe the outside surface with a
damp cloth. Do not immerse. Do not use alcohol or any other cleaning agents, as they may damage the
plastic body.

To clean the reusable needle guard, wipe it with a damp cloth or alcohol swab.

COMMON QUESTIONS

How do I tell how much GENOTROPIN is left in the GENOTROPIN PEN 12?
Look at the dose scale imprinted along the side of the window on the metal front part of the pen. The front
edge of the gray rubber plunger lines up with the number of milligrams remaining in the cartridge.

What happens when the battery runs low?
The battery in the GENOTROPIN PEN 12 should run for two years. When it begins to run low due to the
end of the battery´s life, you will see a flashing symbol ( ) in the dose display. This means the battery will
last about another month. When the battery is dead, the dose display will show a steady . A flashing
"bt" means the battery is running very low for some other reason and will last for about another month.
When the battery is dead, the display will then show a steady "bt".

In either case, call the Pfizer Bridge Program at the toll-free number listed below to exchange your
GENOTROPIN PEN 12 for a new one.

If the battery suddenly dies, can the GENOTROPIN PEN 12 still be used?
Yes. Call the Pfizer Bridge Program at the toll-free number listed below for instructions on how to
determine the dose without the electronic dose display.

Questions about how to use the GENOTROPIN PEN 12?
Call the Pfizer Bridge Program toll-free at (800) 645-1280




Caution: Federal law restricts this device to sale by or on the order of a physician.

LAB-0224-5.0
Revised March 2007