>
Below is a cache of http://www-ermm.cbcu.cam.ac.uk/02005021a.pdf. It's a snapshot of the page taken as our search engine crawled the Web.
The web site itself may have changed. You can check the current page or check for previous versions at the Internet Archive. Yahoo! is not affiliated with the authors of this page or responsible for its content.
Schematic diagram of presenilin 1 Accession information: (02)00502-1a.pdf (short code: fig002dss); 22 August 2002
ISSN 1462-3994 ©2002 Cambridge University Press
http://www.expertreviews.org/
Schematic diagram of presenilin 1
1
expert
reviews
in molecular medicine
Figure 2. Schematic diagram of presenilin 1. (a) Preseniliin 1 (PS1), which contains 467 amino acids, has
eight transmembrane domains, with a large cytoplasmic loop between the sixth and seventh transmembrane
domains. PS2 has a similar structure, but contains 448 amino acids. (b) The large cytoplasmic loop of PS1
comprises residues 265381 (residues given in single-letter code). The endoproteolytic cleavage site (which
generates the two stable fragments) and a putative caspase cleavage site are shown. (c) The binding site for -catenin has been mapped to residues 331351, within the large cytoplasmic loop, whereas the MOCA-
binding site spans the junctional region between the loop and transmembrane domain 7 (residues 375396).
MOCA, modifier of cellular adhesion
(fig002dss).
Schematic diagram of presenilin 1
Expert Reviews in Molecular Medicine
C
2002 Cambridge University Press
82
153
165
211
221
264
381
428
100
132
186
191
241
245
400
408
C
N
Membrane -Catenin-binding site
331
351
375
396
265
1
2
3
4
5
6
7
8
LOOP
K G P L R M L V E T A Q E R N E T L F P A L I Y S S T M V W L V N M A E G D P E A Q R R V S K N S K Y N A E S T E R E S Q D T V A E N D
D G G F S E E W E A Q R D S H L G P H R S T P E S R A A V Q E L S S S I L A G E D P E E R G V K L G L G D F I F Y S V L V G K A S A T A
MOCA-binding site
Capase site (345)
Endoproteolytic site (291)
380
a
b
c