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Schematic diagram of the -amyloid precursor protein ( APP) Accession information: (01)00318-0a.pdf (short code: fig002ggn); 31 May 2001
ISSN 1462-3994 ©2001 Cambridge University Press
http://www-ermm.cbcu.cam.ac.uk
Schematic diagram of the -amyloid precursor protein ( APP)
1
expert
reviews
in molecular medicine
Figure 2. Schematic diagram of the -amyloid precursor protein ( APP).
The amino acids of the -amyloid
(A ) portion of the APP holoprotein are given in single-letter code; N and C refer to the termini of the precursor
protein. The -
,
- and -secretase cleavage sites are indicated. The

-secretase cleaves

at A 1 and
A 11, and -secretase cleaves at A 40 and A 42 within the lipid bilayer; the successive actions of - and -secretases generate A . A is generally described as a 40 or 42 mino acid peptide, but can also be truncated
at the N-terminus by cleavage at Glu11. The most common cleavage by -secretase precludes A formation
(fig002ggn)
.
Cleavage site:
Secretase: -amyloid (A )
A 1
A 11
A 17
A
40
A
42
Lipid bilayer
N
C
D
AEFGHDSGF
E
VRHQK
L
VFFAEDVGSKKGAIIGLMVGGV
V
I
A
Schematic diagram of the -amyloid precursor protein ( APP) -amyloid precursor protein ( APP)
Expert Reviews in Molecular Medicine 2001 Cambridge University Press
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