r; text-indent: 0pt; line-height: 44pt;">Director, Cornell HIV Clinical Trials Unit

Associate Professor of Medicine

Weill Medical College of Cornell University

Slide #2

Antiretroviral Drugs:   

Challenges and Needs

Challenges

Adherence
Toxicity
Activity
Resistance

Needs

Improve convenience
Improve tolerability
Reduce toxicity
Improve activity

wild type virus
resistant virus

Penetrate reservoirs
Exploit new targets

Slide #3

Antiretroviral Drug Approval: 

1987 - 2003

AZT

ddI

ddC

d4T

3TC

SQV

RTV

IDV

NVP

NFV

DLV

EFV

ABC

APV

LPV/r

TDF

ENF

Slide #4

ANTIRETROVIRAL DRUGS 2003

nucleoside RTIs

zidovudine (AZT, ZDV)
didanosine (ddI)
zalcitabine (ddC)
stavudine (d4T)